Nueva carta abierta de prestigiosos científicos en la que se reclama una mayor atención y financiación para la investigación del envejecimiento y su aplazamiento.
Texto original en http://www.imminst.org/cureaging
Traducción y adaptación: Javier Ruiz
Carta abierta de científicos sobre la investigación del envejecimiento
A quien corresponda,
En muchos tipos dispares de animales (C. elegans, Drosophila, ratones enanos Ames, etc.) se ha ralentizado el proceso de envejecimiento y se ha prolongado la expectativa de vida saludable. De igual forma, si asumimos que existen mecanismos fundamentales comunes, también debería ser posible ralentizar el envejecimiento en humanos.
Un mayor conocimiento sobre el envejecimiento debería aportar una mejor gestión de las patologías debilitantes asociadas, tales como el cáncer, las enfermedades cardiovasculares, la diabetes tipo II, y el Alzheimer. Las terapias dirigidas a los mecanismos fundamentales del envejecimiento contribuirán decisivamente a la neutralización de estas patologías relacionadas.
Por lo tanto, esta carta es una llamada a la acción para una mayor financiación e investigación tanto en los mecanismos subyacentes al envejecimiento como en los métodos para su aplazamiento. Tal investigación puede producir beneficios mucho mayores de los que se obtendrían aplicando iguales esfuerzos para combatir las mismas enfermedades relacionadas con el envejecimiento. Conforme los mecanismos del envejecimiento se comprendan mejor, se podrán desarrollar intervenciones cada vez más eficaces que ayudarán a prolongar las vidas útiles, sanas y productivas de muchas personas.
Atentamente (57 firmantes),
Firmas de destacados investigadores en envejecimiento
- Prof. Vladimir N.Anisimov
Head of the Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Russia; Author of Carcinogenesis and Aging and of Molecular and Physiological
Mechanisms of Aging. [04/18/2005]
- Bruce N. Ames,Ph.D.
Professor University of California, Berkeley, Senior Scientist Children’s Hospital Oakland Research Institute; U.S. National Medal of Science; Research in delaying the mitochondrial decay
of aging. [04/25/05]
- RobertArking, Ph.D.
Professor, Dept. of Biological Sciences, Wayne State University; Research focused on understanding the mechanisms underlying the onset of senescence in Drosophila;
Author of Biology of Aging:
Observations and Principles. [10/15/05]
- Steven N. Austad, Ph.D.
Professor, Department of
Biological Sciences at the University of Idaho; Author of Why We Age: What Science Is Discovering about the Body’s Journey
Through Life and numerous other aging research publications. [04/17/05]
- Nir Barzilai, M.D.
Director of the Institute for
Aging Research at the Albert Einstein College of Medicine; Author of numerous
aging research publications; Founder of the Longevity Genes Project. [04/17/05]
- Brian F.C.Clark, Ph.D., ScD.
CoFounder of Senetek PLC, Professor of
Biostructural Chemistry, Aarhus University, Denmark, Centre Leader of
the Danish Centre of Molecular Gerontology. [09/28/05]
- L. Stephen Coles, M.D., Ph.D.
Visiting Professor of Pathology and Laboratory Medicine; UCLA David Geffen School of Medicine, Los Angeles, California; Co-Founder of the Los Angeles Gerontology Research Group; Founding Editor of Rejuvenation Research (formerly The Journal of Anti-Aging Research)[04/06/06]
- T. Michael Cooper, Ph.D., MSEE
Ph.D. in Biological Sciences, Southern Methodist University, (molecular
biology, aging research); formerly Senior Member Technical Staff, Texas
Instruments Inc/Raytheon-TI Systems (retired); Dallas, TX. [04/07/06]
- Antonei B. Csoka,
Department of Obstetrics, Gynecology and
Reproductive Sciences, Division of Developmental and Regenerative Medicine, University of Pittsburgh, Magee-Womens Research Institute; Researchled to the
discovery of the gene that causes Hutchinson-Gilford
Progeria syndrome. [04/18/05]
- Richard G. Cutler, Ph.D,
Vice President of
Kronos Science Laboratories, Inc.,
Longevity Sciences Group; founder of Genox Corporation; Proposed and tested the LongevityDeterminant Gene Hypothesis the Dysdifferentiation Hypothesisof Aging
and the oxidative stress as a primary mechanism of aging model. [04/18/05]
- Aubrey D.N.J. de
Department of Genetics, University of Cambridge,
United Kingdom; Founder of the Strategies for
Engineered Negligible Senescence (SENS) approach to anti-aging medicine; Editor-in-chief of Rejuvenation Research. [04/11/05]
- João Pedro de Magalhães,
Ph.D. in Biological Sciences from the University of
Namur in Belgium; Postdoctoral fellow at Harvard Medical School; Author of a
number of publications on aging; Designed and implemented the Human Ageing Genomic
- Joseph M. Erwin, Ph.D.
Independent Consultant and Executive Director, Foundation for Comparative &Conservation Biology; Adjunct Professor, Biomedical Sciences & Pathobiology and VA-MD Regional College of Veterinary Medicine at VirginiaTech; Senior Fellow, Center for Conservation and Behavior at Georgia Tech;
Co-editor of Aging In Nonhuman
- Leonid A. Gavrilov,
Ph.D.Center on Aging, NORC at the University of Chicago, Chicago; Author of The Biology
of Life Span; Founder of the Reliability Theory of Aging. [04/6/05]
- Natalia S. Gavrilova, Ph.D.
Center on Aging, NORC at the University of Chicago, Chicago; Co-author
of The Biology of Life
Span; Author of over a hundred scientific
publications on aging and
longevity studies. [04/18/05]
- DavidGems, Ph.D.
UCL Centre for Research on Ageing,
Department of Biology,
University College London; Author of numerous aging researchpublications
- DavidGershon, Ph.D.
Skillman Professor of Biomedical Sciences, Technion-Israel Institute of Technology;
Chief Science Officer, Redox Pharmaceutical Corp. [04/18/05]
- S. Mitchell Harman, M.D., Ph.D.
M.D. and Ph.D. SUNY HSC, Brooklyn; Board Certified Internal Medicine and Endocrinology; former Chief, Endocrinology Section, Intramural Research Program, NIA, NIH and Assoc. Prof., Johns Hopkins School of Medicine; current Director and President, Kronos Longevity Research Institute and Clinical Prof. Medicine, U of AZ College of Medicine. Internationally recognized expert in effect of aging on hormone balance and hormone replacement treatment. [04/13/06]
- Christopher B. Heward, Ph.D.
Ph.D. in Biology
from the University of Arizona; Senior Research Fellow in the UCLA Program on
Medicine, Technology, and Society; President of Kronos Science Laboratories,
- Matt Kaeberlein, Ph.D.
Ph.D. in Biology
from The Massachusetts Institute of Technology; Faculty member, The Basic Biology
of Aging at the University of Washington; Co-founder, Longenity Inc.
- Alexander V.Khalyavkin, Ph.D.
Academic Secretary, Gerontological Society of RAS, Moscow Branch; Academic Secretary, Problem Committee “Physiology & Biology of Aging”, JointScientific Council on Gerontology and Geriatrics, Russian Academy of Medical Sciences and Health Ministry; Author of the concept an organism’s non-senescence
due to vital regimens, evoked by positive environmental influences or artificial cues. [04/19/05]
- Marios Kyriazis, M.D.
M.D. from the Univerisity of Rome; MSc in Gerontology from the University of London, King’s College; President of the British Longevity Society; Author of Carnosine: And Other Elixirs of Youth. [04/18/05]
- Don A. Kleinsek, Ph.D.
Received a Ph.D. from the University of Wisconsin at Madison in Physiological Chemistry. President and founder of GeriGene Medical Corporation, in Madison, Wisc. GeriGene’s mission is to stop the aging process. [10/13/05]
- Peter M. Lansdorp M.D., Ph.D.
Professor of Medicine, University of British Columbia; Senior Scientist
Terry Fox Laboratory, B.C. Cancer Research Center; major focus of research on genetic instability inaging and cancer, publications. [09/30/05]
- Marc S. Lewis, Ph.D.
Ph.D. from the University of Cincinnati in Clinical Psychology. Associate Professor at the University of Texas at Austin of Clinical Psychology. Research is focused on the interface of molecular biology and epidemiology withan emphasis on the molecular biology of aging. [06/12/05]
- Valter Longo, Ph.D.
Professor and researcher at the University of Southern California Leonard Davis School ofGerontology, Assistant Professor of Gerontology and Biological Science, Cell Biology and genetics, regulation of aging and multiple stress resistancesystems in yeast and mammals, Alzheimer’s Disease.
- Alvaro Macieira-Coelho,M.D.
Director at the French National Institute of Health (INSERM) in France; Author of numerous books on aging such as Biology of Aging: Progress in Molecular and Subcellular Biology, Cell Immortalization and Cancer and Aging.[04/17/05]
- George M.
Professor Emeritus of Pathology, University of
- Brian J. Morris, Ph.D.
Professor of Molecular Medical Sciences in the School of Medical Sciences of the Faculty of Medicine at The University of Sydney; has over 230 publications; research focusing on the alteration ingenome-wide expression profiles during ageing of human cells. [10/116/05]
- S. Jay Olshansky, Ph.D.
Professor of Epidemiology & Biostatistics at the School of Public Health at the University of Illinois; Co-author with Bruce Carnes of The Quest for Immortality: Science at the Frontiers of Aging. [04/21/05]
- SureshRattan, Ph.D., D.Sc.
Professor, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark; Editor-in-Chief Biogerontology; Editor of Aging Interventions andTherapies
; Research areas and expertise: cellular aging, hormesis (mild stress-mediated aging interventions); gerontogenes.” [09/28/05]
- Robert J. Shmookler Reis,Ph.D.
Professor, Depts. of Geriatrics, Medicine, Biochemistry & Molec.Biol., and Pharmacology; University of Arkansas for Medical Sciences and CareerHealth Scientist, Central Arkansas Veterans Healthcare Service. [09/28/05]
- Karl T. Riabowol, Ph.D.
Professor of Biochemistry & Molecular Biology and Director of the Laboratory of Agingand Immortalization, University of Calgary; Member, Canadian Institutes of Health Research Institute of Aging Advisory Board; extensive publications on aging research. [04/17/05]
- Arlan G.
Institute for Longevity and Aging Studies, The University of Texas Health
Science Center at San Antonio.[04/10/17]
- Michael R. Rose, Ph.D.
Professor in the
Department of Ecology and Evolutionary Biology at the School of Biological
Sciences, University of California, Irvine; Author of Evolutionary Biology of Aging. [04/5/05]
- Stanley Shostak, Ph.D.
Department Biological Sciences,
University of Pittsburgh; Author Becoming Immortal: Combining Cloning and Stem-Cell Therapy and a number of other aging research publications.[09/26/05]
- Rafal Smigrodzki, M.D.,Ph.D.
Chief Clinical Officer, Gencia Company; Charlottesville VA, publications on aging and genetics research [5/24/05]
- Michael D.
Founder of Geron Corporation; Director of Biotime, Inc., BioMarker
Pharmaceuticals, Inc., and the Life Extension Foundation; President of Advanced Cell Technology,
Inc.; Author of The Immortal Cell: One Scientist’s Quest to Solve the Mystery of
Human Aging. [04/18/05]
- Prof. Jan Vijg
Principal investigator at the Functional Genomics of Aging research programwhich is located at the South Texas Center for Biology in Medicine at the Texas Research Park. It ispart of the Sam and Ann Barshop Center for Longevity and Aging Studies. [04/21/05]
- Prof. Thomas von Zglinicki
Professor of Cellular Gerontology, University of Newcastle;
Henry Wellcome Laboratory for Biogerontology, NewcastleGeneral Hospital; extensive publications on aging and telomere research. [04/17/05]
- Firmas de otros destacados científicos
- Nick Bostrom, Ph.D.
Director, Oxford Future of Humanity Institute, Faculty of Philosophy, Oxford University.[09/29/05]
- Daniel Crevier, Ph.D.
Massachusetts Institute of Technology; Former professor, McGill University, Université du Québec.; Founder: Coreco Inc.; Author, AI: The Tumultuous History of the Search for Artificial Intelligence. Basic Books. [09/29/05]
- Gregory Fahy, Ph.D.
Chief Scientific Officer, Vice President; 21st Century Medicine, Inc.; Published anumber of articles on organ perfusion, vitrification and cryopreservation. [06/11/05]
- Robert A. Freitas Jr., J.D.
Senior Research Fellow, Institute for Molecular Manufacturing; Author of Nanomedicine and Kinematic Self-Replicating Machines. [10/01/05]
- BenGoertzel, Ph.D.
Ph.D. in Mathematics from Temple University; Chief Scientific Officer, Biomind LLC, creatingAI-based software for the analysis of gene expression data. [04/27/05]
- AmaraGraps, Ph.D.
Ph.D. in Astrophysics from the University of Heidelberg, Germany; Planetary scientist at the Institute of the Physics of Interplanetary Space in Rome, Italy;Published articles on astronomical dust physics and charging and scientific computing. [09/30/05]
- Robin Hanson, Ph.D.
Associate Professor of Economics, George Mason University
- James J.Hughes, Ph.D.
Executive Director, Institute for Ethics and Emerging Technologies; author Citizen Cyborg; PublicPolicy Studies, Trinity College, Hartford Connecticut. [04/29/05]
- Subhash C. Kak,Ph.D.
Department of Electrical & Computer Engineering, Louisiana State University, Baton Rouge, LA. [09/30/05]
- James B.Lewis, Ph.D.
(Chemistry, Harvard) Senior Research Investigator (retired); Bristol-Myers Squibb Pharmaceutical Research Institute; Seattle,WA
- Max More, Ph.D.
Founder, Extropy Institute; Author of the Proactionary Principle; Austin, TX [09/29/05]
- Brad F. Mellon, STM, Ph.D.
Chair of the Ethics Committee; FrederickMennonite Community; Frederick, PA [09/29/09]
- Steve Omohundro,Ph.D.
(Physics, University of California at Berkeley) Past computer science professor at the University of Illinois at Champaign/Urbana; President, Self-Aware Systems [09/29/05]
- Martine Rothblatt, Ph.D., J.D., M.B.A.
Responsible for launching several satellite communications companies including Sirius and WorldSpace. Founder and CEO of United Therapeutics. Lead the International Bar Association’s project to develop a draft HumanGenome Treaty for the United Nations. Filed the first court motion on AI Legal Rights. [07/02/05]
- Sergey V. Sheleg,M.D., Ph.D.,
Chief Research Scientist, Alcor Life Extension Foundation; M.D. from the Belarus State Medical University and Ph.D. in Oncology from N.N. AlexandrovResearch Institute of Oncology and Medical Radiology (Lesnoy, Belarus). More than 20 published papers in the fields of neuro-ocology, neuro-infectious
diseases, brain anoxia, and molecular cell biology [09/30/05]
- Gregory Stock, Ph.D.
Ph.D. in Biophysics from Johns Hopkins University; MBA from Harvard; Director of the Program on Medicine, Technology, and Society at UCLA’s Schoolof Public Health; Author of Redesigning Humans: Our Inevitable Genetic Future. [04/06/05]
- Brian Wowk, Ph.D.
Ph.D. in Medical Physics from the University of Manitoba, Canada; Senior Scientist 21stCentury Medicine, Inc.; Published a number of articles on medical physics, vitrification andcryopreservation
Publicaciones sobre la plasticidad del
- 2005 Advances
in understanding aging processes and their consequences are leading to the
development of therapies to slow or reverse adverse
changes formerly considered to be “normal” aging and processes that
underlie multiple age-related conditions. Estimating the effectiveness of
candidate aging therapies, whose effects on human aging may require many years
to determine, is a particular challenge. Evan C. Hadley, Edward G. Lakatta,
Marcelle Morrison-Bogorad, Huber R. Warner, and Richard J. Hodes; Cell, Vol
120, 557-567, 25 February 2005.
- 2005 Mutations in genes
affecting endocrine signaling, stress responses, metabolism, and telomeres can
all increase the life spans of model organisms. The
Plasticity of Aging: Insights from Long-Lived Mutants. Cynthia Kenyon. Cell,
Vol 120, 449-460, 25 February 2005.
- 2004 Ames dwarf mice (Prop1df/df) and Little mice
(Ghrhrlit/lit) are used as models of delayed aging and show significant increases in lifespan (50% and 25%,
respectively) when compared with their wild-type siblings.
Amador-Noguez D, Yagi K, Venable S, Darlington G. Aging
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long-term calorie restriction is highly effective in reducing the risk for
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In RNAi-treated C.
elegans, when the reproductive systems is removed, they lived six times as long as normal. Whereas the mean
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In yeast (S. cerevisiae),
overexpression of PNC1 extends the replicative life
span by 70% in a Sir2-dependent manner. Kevin J. Bitterman, Oliver
Medvedik, and David A. Sinclair; Microbiol Mol Biol Rev. 2003 September;
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CureAging.org: Carta abierta independiente en apoyo de la investigación del envejecimiento.
Para añadir firmas u obtener más información, escribir a: firstname.lastname@example.org
- Nick Bostrom, Ph.D.