Curriculum Vitae (2004)

Academic Position
Full time Researcher: since 1992 National University of Mexico

Education
1988-1992 Ph.D. Weizmann Institute of Science, Rehovot, Israel.
Dissertation: The mRNA Framing Pattern Refined through the Analysis of Nucleotide Distributions and Signal Component Compensations with Dr. Edward N. Trifonov
1984-1986 M.Sc. in Life Sciences, Weizmann Institute of Science
Thesis: Ribosomal Structure Derived from Sequence Analysis with Dr. Edward N. Trifonov
1979-1984 B.Sc.: Basic Biomedical Research, UNAM, Mexico.
Thesis: Computational Programs Applied to Biological Sequences with Dr. José Negrete Martínez

Recognitions
Assignment of Fellowship from the Rotary Club of Morelos (1987)
Assignment of SEP/IPN-CONACyT fellowship (1984)
Recipient of the JFK y Feinberg Foundation Fellowship from the Weizmann Institute of Science, Israel (1987-1992)
Recipient of Fellowship from the USA-Mexico Binational Foundation through the National Academy of Sciences of Mexico for a scientific visit at Rockefeller University in NYC. (July, 1995)
Who’s who in the World, 1999

Patents in process of Registration
Oligonucleotide for HIV RT inhibition
Oligonucleotide for therapeutics in Breast Cancer

General Information
2004 Referee for CONACYT scientific projects in Mexico.
2001-2003 Director for PostDoctorant
1999 Referee for contributions to the 1998 Pacific Symposium on Biocomputing., Interviewed by Channel 5 and channel 7 for national broadcast in Mexico.
1996 Referee for COLCIENCIAS science and technology agency of Colombia.
1996-2002 Member of the Commitee for Supercomputing of the National University of Mexico
1995-2002 Coordinator of-a project (Genia) for the design of asystem that can analyze of protein and genetic networks.
1993-1996 Mentor of two PhD students, and two B.Sc. students. Member of three PhD Tutorial Comitees

Consulting
1998 Biotechnological patent application analysis.
1990-1991 Computational Analysis of DNA sequences at the Center of Nitrogen Fixation of the U.N.A.M., Cuernavaca, Morelos, Mexico.
1987, 1988 Computational Analysis of DNA sequences. at the Institute of Biomedical Research of the U.N.A.M. México, City, Mexico
1981-1983 Design and development of code for an automatic system of format transcription of telegrams and money orders for the Secretariat of Communications and Transportation.

Talks
Universidad Autonoma del Estado de Morelos, Mexico, 2004.
Institute of Materials Research, UNAM, México, 2003.
T. Blundell Laboratory, Cambridge, UK, January, 1997.
Rockfeller University, Laboratory of F. Nottembaum, NY, 1995.
Posgraduate Department of Faculty of Chemistry, UNAM, 1995.
Instituto de Investigaciones Biomédicas, UNAM, 1995

Participation in Meetings
Ipcat 2001, Session Chairman WSEAS, Jaimaica 2000, Satphys 2001, International Conference on Complex Systems Boston, Mass. September,. 1997., 1st. UICC (Union Internationale Contre le Cancer) meeting on Cancer management, Vienna, Austria, 1997. International Meeting on Intelligent Systems for Molecular Biology, Halkidiki, Greece, 1997. The Fifth International Nature Genetics conference on Functional Genomics: From Genes to Drugs Washington, D.C. 1997. International Meeting on Bioinformatics, Jerusalem, Israel, November, 1996. International Meeting on Bioinformatics, Baltimore, Md. USA, June, 1996. International Meeting on Bioinformatics, Sn. Francisco, Cal., USA, June, 1995. International Meeting on Oligonucleotide Therapies, Sn Diego, Cal. USA June, 1995. International Congress on Biochemistry and Molecular Biology, New Delhi, India, September, 1994. First International Conference on Intelligent Systems for Molecular Biology Washington, D.C., July, 1993. Sante Fe Conference on Computational Biology, Santa Fe, N.M, November, 1992. Computational Methods in Genome Research, Heidelberg, Germany, July, 1992.

Receptor of Research Grants
Computer applications in genetic analysis:
DGAPA, 1994, Conacyt 1995, DGAPA, 1996-1998, 2000-2002

Organizations
Member or the National System of Researchers (SNI) of Mexico NECSI

Publications
Chapters in Books
1 Compensation effects in the framing code, J. Lagúnez Otero & E. Trifonov, En "Modeling and Computer Methods in Molecular Biology and Genetics", Ed. V. Ratner, Nova Science Publishers, New York. 1992.

2 Signal Transduction Analysis Using with Boolean Paradigms M. Armas, O. Armas, M. Cardenas, J. Vasconcelos & J. Lagúnez-Otero in Mathematics and Computers in Modern Science, N. Mastorakis, ed. World Scientific Engineering Society Press, ISBN:960-8052-23, pp 269-174., 2000.

3 Modeling intracellular signaling networks using behaviour-based systems and blackboard architecture, P.P. González, C. Gershenson, M. Cárdenas, J. Lagúnez-Otero , in Mathematics and Computers in Modern Science, N. Mastorakis, ed. World Scientific Engineering Society Press, ISBN:960-8052-23, p 219-22., 2000.

Articles
Integration of Computational Techniques for the Modelling of Signal Transduction Pedro Pablo González, Maura Cárdenas, Carlos Gershenson, Jaime Lagúnez-Otero en Advances in Systems Science: Measurement & Control, ISBN:960-8052-39, p 400-410, 2001. mRNA infrastructure complementary to the proofreading site of the ribosome, J. Lagúnez Otero & E. Trifonov, (J. of Biomol. Struct. and Dyn. 10, 455-464 1992).

A plasmidic Citrate Synthase increases symbiotic fitness in Rhizobium tropici, M.A. Pardo, J. Lagúnez-Otero & E. Martínez-Romero (J. Mol. Microb., 11,2 315-321, 1993).

Complementarity of mRNA to the 530 loop of SS rRNA - implications for Initiation, J. Lagúnez-Otero (Trends in Biochemical Sciences. 18,11:406-8, 1993 (Factor de impacto 14.3).

The Ribosome as an Exon Detector, Mendoza, L. Lagúnez-Otero, (Biosystems, 38, 45-49, 1996).

Nutritional Value of Edible Insects from Oaxaca, Mexico Julieta Ramos, Pino, M., E., Ladrón de Guevara, O, Lagúnez -Otero, J. (J of Food and Nutrition, 10, 142-157, 1997)

Taxonomy of 5S Ribosomal RNA by the Linguistic Technique: Probing Mitochondrial and Mammalian Sequences, Cardoso Guimarães, R., Trifonov, E. N. & Lagunez-Otero, J. (J. Mol. Evol. 45 (3): 271-277, 1997).

Ab Initio Study of the Acetone Performic Acid Baeyer & Villiger Reaction Mechanism Cardenas, R., Cetina, R., Lagúnez-Otero, J., and Reyes, L. (JPC of the ACS, 101, 192-200, 1997).

Ab Initio Study of the Reaction Mechanism of Water Dissociation into the Ionic Species OH^- and H₃O⁺, R. Cárdenas*, J. Lagúnez-Otero and A. Flores**, J., (Journal of Quantum Chemistry, 68, 253-259, 1997).

The Role Played by the 530 Ribosomal Site in Translocation - Interaction with the termination region of mRNA, Mendoza, L., Mondragón, M., and Lagúnez-Otero, J (Biosystems 46, 293-298, 1998).

Semiempirical Studies on the Transition Structure of the Baeyer & Villiger Rarrangement, the reaction of acetone with alkyl and acyl peracids. Renán Cárdenas, Lino Reyes, Jaime Lagúnez-Otero & Raúl Cetina. J. Mol. Structure 497: 211-225, 2000.

Specialized biology from tandem B-turns. Jaime Lagúnez-Otero,¹ Andrea Diaz-Villaseñor, ¹ and V. Renugopalakrishnan,¹, Arch Med Res May-Jun; 33 (3):245-249 2002

The application of abstract topology to RAS-related signal transduction pathways Maura Cárdenas-García ^a,1, Jaime Lagunez Otero ^a,2 and Nikolai A. Korneev ^b,3 In Silico Biology 2, 40, 2002.

Cellulat: an agent based intracellular signalling model, Pedro Pablo González, Maura Cárdenas, David Camacho, Armando Franyuti, Octavio Rosas and Jaime Lagúnez-Otero Biosystems,.68, 171-185, 2003.

Proceedings
1. Use of subgroups for the Analysis of Protein Interations in the Cell, M. Cárdenas-García, N., Kornieev, and J. Lagúnez Otero, A Topology of Protein Interaction Networks, (ISMB 2000, Proceedings of the Eighth International Conference on Intelligent Systems for Molecular Biology, Altman R. et al. Editores. AAAI Press, p86-92) 2000.

2. Cellulat, Jaime Lagunez-Otero, Pedro Pablo González, Maura Cárdenas, Octavio Roas, & Armando Franyuti, in Artificial Life VIII, Standish, Abass, Bedau (eds) (MIT Press) 2002. pp97-100.

Reports
1 Towards Phenotypic Engineering, J. Lagúnez-Otero, M. Strauch, M. Armas Alemán (Abstract) (Folding and Design, Vol. 1, Sup, S4-S5, 1996)