Firmas de otros destacados científicos

• Nick Bostrom, Ph.D.
  Director, Oxford Future of Humanity Institute, Faculty of Philosophy, Oxford University. [09/29/05]
  
  
• Daniel Crevier, Ph.D.
  Massachusetts Institute of Technology; Former professor, McGill University, Université du Québec.; Founder: Coreco Inc.; Author, AI: The Tumultuous History of the Search for Artificial Intelligence. Basic Books. [09/29/05]
  
  
• Gregory Fahy, Ph.D.
  Chief Scientific Officer, Vice President; 21st Century Medicine, Inc.; Published a number of articles on organ perfusion, vitrification and cryopreservation. [06/11/05]
  
  
• Robert A. Freitas Jr., J.D.
  Senior Research Fellow, Institute for Molecular Manufacturing; Author of Nanomedicine and Kinematic Self-Replicating Machines. [10/01/05]
  
  
• Ben Goertzel, Ph.D.
  Ph.D. in Mathematics from Temple University; Chief Scientific Officer, Biomind LLC, creating AI-based software for the analysis of gene expression data. [04/27/05]
  
  
• Amara Graps, Ph.D.
  Ph.D. in Astrophysics from the University of Heidelberg, Germany; Planetary scientist at the Institute of the Physics of Interplanetary Space in Rome, Italy; Published articles on astronomical dust physics and charging and scientific computing. [09/30/05]
  
  
• Robin Hanson, Ph.D.
  Associate Professor of Economics, George Mason University [09/29/05]
  
  
• James J. Hughes, Ph.D.
  Executive Director, Institute for Ethics and Emerging Technologies; author Citizen Cyborg; Public Policy Studies, Trinity College, Hartford Connecticut. [04/29/05]
  
  
• Subhash C. Kak, Ph.D.
  Department of Electrical & Computer Engineering, Louisiana State University, Baton Rouge, LA. [09/30/05]
  
  
• James B. Lewis, Ph.D.
  (Chemistry, Harvard) Senior Research Investigator (retired); Bristol-Myers Squibb Pharmaceutical Research Institute; Seattle, WA [09/29/05]
  
  
• Max More, Ph.D.
  Founder, Extropy Institute; Author of the Proactionary Principle; Austin, TX [09/29/05]
  
  
• Brad F. Mellon, STM, Ph.D.
  Chair of the Ethics Committee; Frederick Mennonite Community; Frederick, PA [09/29/09]
  
  
• Steve Omohundro, Ph.D.
  (Physics, University of California at Berkeley) Past computer science professor at the University of Illinois at Champaign/Urbana; President, Self-Aware Systems [09/29/05]
  
  
• Martine Rothblatt, Ph.D., J.D., M.B.A.
  Responsible for launching several satellite communications companies including Sirius and WorldSpace. Founder and CEO of United Therapeutics. Lead the International Bar Association's project to develop a draft Human Genome Treaty for the United Nations. Filed the first court motion on AI Legal Rights. [07/02/05]
  
  
• Sergey V. Sheleg, M.D., Ph.D.,
  Chief Research Scientist, Alcor Life Extension Foundation; M.D. from the Belarus State Medical University and Ph.D. in Oncology from N.N. Alexandrov Research Institute of Oncology and Medical Radiology (Lesnoy, Belarus). More than 20 published papers in the fields of neuro-ocology, neuro-infectious diseases, brain anoxia, and molecular cell biology [09/30/05]
  
  
• Gregory Stock, Ph.D.
  Ph.D. in Biophysics from Johns Hopkins University; MBA from Harvard; Director of the Program on Medicine, Technology, and Society at UCLA’s School of Public Health; Author of Redesigning Humans: Our Inevitable Genetic Future. [04/06/05]
  
  
• Brian Wowk, Ph.D.
  Ph.D. in Medical Physics from the University of Manitoba, Canada; Senior Scientist 21st Century Medicine, Inc.; Published a number of articles on medical physics, vitrification and cryopreservation. [04/23/05]
  

Publicaciones sobre la plasticidad del envejecimiento

• 2005 Advances in understanding aging processes and their consequences are leading to the development of therapies to slow or reverse adverse changes formerly considered to be “normal” aging and processes that underlie multiple age-related conditions. Estimating the effectiveness of candidate aging therapies, whose effects on human aging may require many years to determine, is a particular challenge. Evan C. Hadley, Edward G. Lakatta, Marcelle Morrison-Bogorad, Huber R. Warner, and Richard J. Hodes; Cell, Vol 120, 557-567, 25 February 2005.
  
  
• 2005 Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all increase the life spans of model organisms. The Plasticity of Aging: Insights from Long-Lived Mutants. Cynthia Kenyon. Cell, Vol 120, 449-460, 25 February 2005.
  
  
• 2004 Ames dwarf mice (Prop1df/df) and Little mice (Ghrhrlit/lit) are used as models of delayed aging and show significant increases in lifespan (50% and 25%, respectively) when compared with their wild-type siblings. Amador-Noguez D, Yagi K, Venable S, Darlington G. Aging Cell. 2004 Dec;3(6):423-41.
  
  
• 2004 In humans, long-term calorie restriction is highly effective in reducing the risk for atherosclerosis. Fontana L, Meyer TE, Klein S, Holloszy JO. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6659-63.
  
  
• 2003 In RNAi-treated C. elegans, when the reproductive systems is removed, they lived six times as long as normal. Whereas the mean life-span of wild type was 20 days, these animals had mean life-spans of 124 days. Healthy animals with extreme longevity. Arantes-Oliveira N, Berman JR, Kenyon C. Science. 2003 Oct 24;302(5645):611.
  
  
• 2003 In yeast (S. cerevisiae), overexpression of PNC1 extends the replicative life span by 70% in a Sir2-dependent manner. Kevin J. Bitterman, Oliver Medvedik, and David A. Sinclair; Microbiol Mol Biol Rev. 2003 September; 67(3): 376–399.
  
  
• 2003 In humans, Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by features reminiscent of marked premature ageing. The discovery of the molecular basis of this disease may shed light on the general phenomenon of human ageing. Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM, Moses TY, Berglund P, Dutra A, Pak E, Durkin S, Csoka AB, Boehnke M, Glover TW, Collins FS. Nature. 2003 May 15;423(6937):293-8.
  
  
• 2002 Indefinite postponement of aging – which we term "engineered negligible senescence" – may be within sight. Given the major demographic consequences if it came about, this possibility merits urgent debate. Time to Talk SENS: Critiquing the Immutability of Human Aging; Aubrey D. N. J. de Grey, Bruce N. Ames, Julie K. Andersen, Andrzej Bartke, Judith Campisi, Christopher B. Heward, Roger J. M. McCarter and Gregory Stock; Annals of the New York Academy of Sciences 959:452-462 (2002)
  
  
• 2001 Mutant mice with a combined deficiency of growth hormone (GH), prolactin, and thyrotropin, and knockout mice with GH resistance, live longer than their normal siblings. The extension of life span in these animals is very large (up to 65%), reproducible, and not limited to any particular genetic background or husbandry conditions. Bartke A, Coschigano K, Kopchick J, Chandrashekar V, Mattison J, Kinney B, Hauck S. J Gerontol A Biol Sci Med Sci. 2001 Aug;56(8):B340-9.
  
  
• 2001 Mice homozygous for loss-of-function mutations at the Pit1 (Snell dwarf) locus show a >40% increase in mean and maximal longevity on the relatively long-lived (C3H/HeJ x DW/J)F(1) background. Findings demonstrate that a single gene can control maximum lifespan and the timing of both cellular and extracellular senescence in a mammal. Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6736-41.
  
  
• 2000 In Drosophila, five independent P-element insertional mutations in a single gene resulted in a near doubling of the average adult life-span without a decline in fertility or physical activity. Rogina B, Reenan RA, Nilsen SP, Helfand SL.; Science. 2000 Dec 15;290(5499):2137-40.
  
  
• 1999 In mice, suppression of p66shc protein extends the life span by 30%. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG.; Nature. 1999 Nov 18;402(6759):309-13.
  
  
• 1998 Low caloric intake (caloric restriction) can lengthen the life span of a wide range of animals and possibly even of humans. Specific mutations significantly lengthen life span by up to 50%. Lakowski B, Hekimi S.; Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13091-6.
  
  
• 1998 In Drosophila, overexpression of a single gene, SOD1, in a single cell type, the motorneuron, extends normal lifespan by up to 40% and rescues the lifespan of a short-lived Sod null mutant. Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL.; Nat Genet. 1998 Jun;19(2):171-4.
  
  
• 1993 Mutations in the gene daf-2 can cause C. elegans to live more than twice as long as wild type. Kenyon, C.J., Chang, Gensch, E., J. Rudner, A. and Tabtiang, R.; Nature. 1993 Dec 2;366(6454):461-4.
  
  
  

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